A prospective study of physical trauma and multiple sclerosis.

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A prospective study of physical trauma and multiple sclerosis.

During an eight year period 170 multiple sclerosis (MS) patients and 134 controls without physical impairment were followed closely to record all episodes of physical trauma and to measure their effect on exacerbation rate and progression of MS. There was a total of 1407 instances of trauma, which were sorted into various categories. Overall there was no significant correlation between all-trau...

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Physical trauma and risk of multiple sclerosis: A systematic review and meta-analysis of observational studies

BACKGROUND We aimed to examine physical trauma as a risk factor for the subsequent diagnosis of MS. METHODS We searched for observational studies that evaluated the risk for developing MS after physical trauma that occurred in childhood (≤20 years) or "premorbid" (>20 years). We performed a meta-analysis using a random effects model. RESULTS We identified 1362 individual studies, of which 3...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1992

ISSN: 0022-3050

DOI: 10.1136/jnnp.55.6.524-b